Buckling without bending morphogenesis: Nonlinearities, spatial confinement, and branching hierarchies

On Buckling Morphogenesis.

Cell-generated mechanical forces drive many of the tissue movements and rearrangements that are required to transform simple populations of cells into the complex three-dimensional geometries of mature organs. However, mechanical forces do not need to arise from active cellular movements. Recent studies have illuminated the roles of passive forces that result from mechanical instabilities betwe...

Spatial mapping and quantification of developmental branching morphogenesis.

Branching morphogenesis is a fundamental developmental mechanism that shapes the formation of many organs. The complex three-dimensional shapes derived by this process reflect equally complex genetic interactions between branching epithelia and their surrounding mesenchyme. Despite the importance of this process to normal adult organ function, analysis of branching has been stymied by the absen...

Branching morphogenesis.

Tubular structures are a fundamental anatomic theme recurring in a wide range of animal species. In mammals, tubulogenesis underscores the development of several systems and organs, including the vascular system, the lungs, and the kidneys. All tubular systems are hierarchical, branching into segments of gradually diminishing diameter. There are only 2 cell types that form the lumen of tubular ...

Bending and buckling of wet paper

Cytoskeletal bundle bending, buckling, and stretching behavior

F-actin bundles constitute principal components of a multitude of cytoskeletal processes including stereocilia, filopodia, microvilli, neurosensory bristles, cytoskeletal stress fibers, and the sperm acrosome. The bending, buckling, and stretching behaviors of these processes play key roles in cellular functions ranging from locomotion to mechanotransduction and fertilization. Despite their cen...